Ateş, B Özel Çağsu Hastanesi - Ortopedi ve Travmatoloji Birimi, Turkey , Seyfettinoğlu, F İzmir Atatürk Eğitim Araştırma Hastanesi - Ortopedi ve Travmatoloji Kliniği, Turkey , Ateş, Z Abant İzzet Baysal Üniversitesi - Tıp Fakültesi - Fizik Tedavi ve Rehabilitasyon Anabilim Dalı, Turkey , Duygun, F Özel Medisina Hastanesi - Ortopedi ve Travmatoloji Birimi, Turkey , Uca, T Özel Çağsu Hastanesi - Ortopedi ve Travmatoloji Birimi, Turkey

Comparison of the results of intra-articular hyaluronic acid and oral glucozaminosulfate treatment after arthroscopic debridement in patients with degenerative knee osteoarthritis

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Objective: In this study we compare the early clinical results of the intra-articular hyaluronic acid and oral glucosaminosulfate treatment after arthroscopic debridement in patients with degenerative knee osteoarthritis.Materails and Methods: Studies were conducted between January 2005-2009 on 89 patients who had arthroscopic debridement, 64 patients who have Outerbridge grade 1 and grade 2 cartilage damage on the medial femoral condyle, who do not have varus or valgus deformity and have had not applied for a knee operation. All the patients are female and their average age is 55.8 years. After arthroscopy, patients were divided into two groups containing 32 patients each. In the first group, 21 days after the debridement, we applied once a week intra-articular 30 mg/2 ml sodium hyaluronate three times. In the second group, 21 days after the debridement, a daily dose of 1500 mg/day oral glucozaminosulfate was administered for three months. Patients were evaluated before the operation, on the 21st day after operation and 12 months after the treatment with visual analog scale (VAS). Results: In the first group, before the operation, the average VAS score of the 32 patients was 8.56 and in the third week after the operation the average VAS score was 3.28. The difference was found to be statistically significant (p 0.05). In this group, the average VAS score after hyaluronate treatment was 2.22. The difference between the average VAS scores after operation and after treatment was not significant (p 0.05). In the second group, before the operation, the average VAS score of the 32 patients was 8.56 and in the third week after the operation the average VAS skore was 3.22. The difference was found to be statistically significant (p 0.05). In this group, the average VAS score after oral glucozamin treatment for three months was 2.38. The difference between the average VAS scores after operation and after treatment was not significant (p 0.05).Conclusion: This study shows that arthroscopic debridement is significantly useful to reduce the pain in the early and intermediate period in patients with outerbridge type 1- 2 cartilage damage but after arthroscopic procedure. sodium hyaluronate and glucozamine treatments did not provide significant additional contributions.

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Knee osteoarthritis , arthroscopy , hyaluronic acid , glucosamine sulfate

Ege Journal Of Medicine

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