Author/Authors :
Acarer, A Ege Üniversitesi - Tıp Fakültesi - Nöroloji Anabilim Dalı, Turkey , Kıraç, L B Ege Üniversitesi - Tıp Fakültesi - Nöroloji Anabilim Dalı, Turkey , Bademkıran, F Ege Üniversitesi - Tıp Fakültesi - Nöroloji Anabilim Dalı, Turkey , Karapınar, N Seda Hastanesi - Nöroloji Birimi, Turkey , Çolakoğlu, Z Ege Üniversitesi - Tıp Fakültesi - Nöroloji Anabilim Dalı, Turkey
Abstract :
Aim: Psychotic symptoms associated with Parkinson’s disease (PD) can lead to a serious condition that can increase mortality and hospitalization rates and can have a major impact on caregivers’ quality of life. In this study, we evaluated the efficacy and safety of olanzapine and quetiapine treatments in patients with PD who suffer from psychosis. Materials and Methods: We retrospectively inspected the files of patients who were diagnosed with PD. Among the patients who developed psychosis, 32 of them who used or were using quetiapin and olanzapin were enrolled in the study. The treatment response, deterioration of motor symptoms and interruption of treatment due to adverse effects were all evaluated.Results: In the group of the 32 patients, 20 had received olanzapin and 12 received quetiapine. Seven patients who received olanzapin presented an improvement of their condition, seven patients had motor worsening. Three subjects interrupted the use of olanzapine since it failed to induce the desired effect and three subjects interrupted due to adverse effects. Among the patients who received quetiapine, 10 presented an improvement. In one patient quetiapine was discontinued due to ineffectiveness and in another patient due to adverse effects.Conclusion: In our study treatment with quetiapine was found to be superior to olanzapine since it causes less worsening of motor functions and fewer side effects.
NaturalLanguageKeyword :
Quetiapine , olanzapine , Parkinson’s disease , psychosis , antipsychotic drugs
