Soylar, M Ege Üniversitesi - Tıp Fakültesi - Tıbbi Mikrobiyoloji Anabilim Dalı, Turkey , Altuğlu, İ Ege Üniversitesi - Tıp Fakültesi - Tıbbi Mikrobiyoloji Anabilim Dalı, Turkey , Sertöz, R Ege Üniversitesi - Tıp Fakültesi - Tıbbi Mikrobiyoloji Anabilim Dalı, Turkey , Aydın, D Ege Üniversitesi - Tıp Fakültesi - Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Turkey , Akkoyun, F Ege Üniversitesi - Tıp Fakültesi - Nöroloji Anabilim Dalı, Turkey , Zeytinoğlu, A Ege Üniversitesi - Tıp Fakültesi - Tıbbi Mikrobiyoloji Anabilim Dalı, Turkey

Viral agents in patients with central nervous infections admitted to Ege University Hospital

14849

Aim: Central Nervous system (CNS) infections require a rapid diagnosis and treatment approach due to their potential of rapid progression and the possibility of permanent neurological damage. In this study, viral agents detected by nucleic acid tests in the cerebrospinal fluid samples of patients with a suspicion of viral CNS infection were sent to Medical Microbiology Laboratory of Ege University Hospital and evaluated.Materials and Methods: A total number of 289 CSF samples submitted to Medical Microbiology Laboratory from January 2012 to December 2012 for viral nucleic acid testing were evaluated retrospectively. One hundred ninety eight CSF samples were tested for HSV DNA (HSV LightCycler ½ Qual Kit, Roche, Germany), 46 samples for CMV DNA (CMV Fluorion QNP 3.0 Real-Time PCR, İontek, Turkey), 20 samples for EBV DNA (Lightmix Kit Epstein-Barr virus, TIB MOLBIOL, Germany) and 25 samples for Enterovirus RNA (GeneXpert Xpert EV, Cepheid, USA).Results: One hundred fifty three patients were females and 136 were males, ages ranging from 0 to 88 (median age 39) years. HSV DNA was detected by nucleic acid testing in two of the 198 patients (1%), CMV DNA in one of the 46 patients (2%), EBV DNA three of the 20 patients (15%) and enterovirus RNA in one of the 25 patients (4%). Conclusion: Even though CNS infections are not rare, the incidence is not clearly established. Due to high mortality rate and potential of neurological damage, they are extremely important. Even though the etiology is unknown in many cases, the development of molecular techniques has increased the detection rate of viral agents.

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Central nervous system infections , viral encephalitis , viral meningitis

Ege Journal Of Medicine

70