URAL, Ulku Mete Zekai Tahir Burak Women s Health Education and Research Hospital, Turkey , AVSAR, Ayse Filiz Zekai Tahir Burak Women s Health Education and Research Hospital, Turkey , DANISMAN, Nuri Zekai Tahir Burak Women s Health Education and Research Hospital, Turkey , AYTAC, Pınar Caglar Zekai Tahir Burak Women s Health Education and Research Hospital, Turkey , ALTUAKAR, Baran Zekai Tahir Burak Women s Health Education and Research Hospital, Turkey

Correlation of mid-trimester homocysteine, vitamin B12 and folate levels with adverse pregnancy outcomes: A clinical study

14909

Aim: The aim of this study is to determine if maternal serum levels of folate, vitamin B12 and homocysteine at 20-26 weeks of gestation are associated with subsequent adverse pregnancy outcomes. Materials and Methods: This prospective study was conducted in a tertiary care center and included 159 pregnant women at 20-26 gestational weeks. Complicated and uncomplicated pregnancy groups were compared in terms of serum levels of folate, vitamin B12, and homocysteine using Mann-Whitney U and t tests. Correlation of homocysteine with vitamin B12 and folate were analyzed with regression analysis. Results: Of the 159 participants, 32 (20.13%) suffered from pregnancy complications. There were no significant differences in the levels of the midtrimester homocysteine (p=0.25) and vitamin B12 (p=0.19) between healthy and complicated pregnancy groups. The significant difference in terms of folate levels (p=0.02) was considered to be clinically insignificant, since the measured levels were within normal range. There is a statistically significant inverse correlation between homocysteine and vitamin B12 levels (r = -0.407, p=0.013). Conclusion: Our results indicate that homocysteine, vitamin B12 and folate concentrations in mid-trimester are not associated with adverse pregnancy outcomes. These findings suggest that these markers seem not to have predictive value for pregnancy complications

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Complication , folate , homocysteine , midtrimester , pregnancy , vitamin B12

Ege Journal Of Medicine

82