YILMAZ, İhsan Beyoğlu Eye Training and Research Hospital - Clinic of Ophthalmology, Turkey , AYGIT, Ebru Demet Beyoğlu Eye Training and Research Hospital - Clinic of Ophthalmology, Turkey , KARAMAN ERDUR, Sevil Medipol Hospital - Clinic of Ophthalmology, Turkey , DEMİROK, Ahmet Beyoğlu Eye Training and Research Hospital - Clinic of Ophthalmology, Turkey

Results of subconjunctival 5-fluorouracil in the management of bleb failure: A case series

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Aim: To evaluate the efficacy of 5-Fluorouracil (5-FU) injections in eyes with bleb failure and uncontrolled intraocular pressure (IOP) after trabeculectomy. Materials and Methods: Fifteen eyes of 15 patients (6 female, 9 male) were included in this retrospective study. All patients had trabeculectomy surgery for the treatment of primary open angle glaucoma. During the first year follow-ups, cases with IOP higher than 21 mmHg and ineffective blebs were considered as bleb failure. We used 5-FU subconjunctival injections, in the same concentration (5 mg) but in different numbers, to treat the bleb failure and lower the IOP. The efficacy of the treatment was evaluated. Results: The mean age was 59.3±12.4 years (range 43-74 years). The mean 5-FU injection count was 5.27±1.58 injections (range 2-7). The mean IOP was reduced to 17.07±7.10 mmHg after treatment. There was a statistically significant difference in IOP levels before and after the injections (p 0.05). Conclusion: 5-FU injection treatment is safe and effective for the treatment of bleb failure after trabeculectomy

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Trabeculectomy , bleb failure , 5 , FU , 5 , fluorouracil

Ege Journal Of Medicine

113