Gürsoy, Kevser Burdur Devlet hastanesi - Çocuk Cerrahisi Klinigi, Turkey , Savaş, M. Çağrı Süleyman Demirel Üniversitesi - Tip Fakültesi - Çocuk Cerrahisi A D, Turkey , Kaya, Selçuk Süleyman Demirel Üniversitesi - Tip Fakültesi - Mikrobiyoloji AD, Turkey , Gürsoy, Ayhan Burdur Devlet Hastanesi - Radyoloji Klinigi, Turkey , Büyükyavuz, B. İlker Süleyman Demirel Üniversitesi - Tip Fakültesi - Çocuk Cerrahisi A D, Turkey , Özgüner, İ. Faruk Sami Ulus Çocuk Hastanesi - Çocuk Cerrahisi Klinigi, Turkey

Hormonal therapy in children with undescended testis: a prospective clinical trial

15470

Objective: It is aimed to investigate the effects of human chorionic gonadotrpin (hCG) treatment on testicular descent and volume, penile length, serum antisperm antibodies (ASA), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and total testosterone levels in children with undescended testis (UDT). Materials and Methods: 46 prepubertal children with UDT were included in the study. Patients were divided into two groups as Placebo (n=17) and Pregnyl (n=29). 6 of 29 patients (20,6%) in Pregnyl group were excluded from the study as testicular descend was achieved with the hormonal treatment. Pregnyl group (n=23) received 100 IU/kg i.m. dose of hCG once a week for 3 weeks. Placebo group received i.m. SF injections once a week for 3 weeks. Orchiopexy was performed each patients in 1 week after the medical treatment. Testicular locations and volumes were determined with USG; penile lengths, serum levels of ASA, total testosteron, FSH and LH were measured before the treatment and one month after the surgery. Results: The penile length, testicular volume and serum total testosterone level were increased significantly in Pregnyl group following surgery (p 0,001). However, no significant differences were detected in serum ASA, FSH and LH levels before and after the treatment in both groups. Conclusion: Hormonal treatment with hCG may provide testicular descent and may be considered as a treatment modality prior to surgery in children with UDT. Serum ASA levels, which may have an influence on the infertility, does not changes with the hormonal treatment before and after the surgery. This finding, beside the testicular descent, also supports the hormonal treatment option prior to surgery in children with UDT.

14

Undescended testis , hCG , antisperm antibody

Medical Journal Of Suleyman Demirel University

18