Author/Authors :
Küçüktepe, Zehra Süleyman Demirel Üniversitesi - Tip Fakültesi - Kardiyoloji AD, Turkey , Özaydın, Mehmet Süleyman Demirel Üniversitesi - Tip Fakültesi - Kardiyoloji AD, Turkey , Türker, Yasin Gülkent Devlet Hastanesi - Kardiyoloji Klinigi, Turkey , Varol, Ercan Süleyman Demirel Üniversitesi - Tıp Fakültesi - Kardiyoloji AD, Turkey , Erdoğan, Doğan Süleyman Demirel Üniversitesi - Tip Fakültesi - Kardiyoloji AD, Turkey , Doğan, Abdullah Süleyman Demirel Üniversitesi - Tip Fakültesi - Kardiyoloji AD, Turkey , Hiçyılmaz, Hicran Süleyman Demirel Üniversitesi - Tip Fakültesi - Biyokimya AD, Turkey , Vural, Hüseyin Süleyman Demirel Üniversitesi - Tip Fakültesi - Biyokimya AD, Turkey
Abstract :
Objective: The main objective of this study was to compare the plasma asymmetric dimethylarginine (ADMA) levels between the patients with isolated coronary artery ectasia (CAE) and individuals with normal coronary arteries or patients with coronary artery disease (CAD) (diameter loss 50%). Methods Eighty-eight consecutive patients meeting study inclusion criteria who have undergone coronary angiography between August 2007 and February 2008, were participated in this study. All patients were separated into three groups: CAE, CAD and normal coronary artery. Serum levels of ADMA were measured by using ELISA method and nitric oxide metabolites levels were measured by using photometric method. Results: Although statistically insignificant, serum levels of ADMA was lower in patients with CAE than CAD (p1: 0.058) or normal coronary arteries (p2: 0.08). There was no statistically significantly difference between CAE, normal coronary arteries or CAD with regard to nitric oxide levels. Conclusion: There was no statistically significant difference between CAE, normal coronary arteries and CAD with regard to plasma ADMA levels but there was a trend of lower plasma ADMA levels in patients with CAE compared to normal coronary arteries or CAD.
