Author/Authors :
Aköz, Mehmet University of Selçuk - Faculty of Meram Medicine - Department of Biochemistry, Turkey , Karagözoglu, Emrah Konya Numune Hospital - Clinical Biochemistry Laboratory, Turkey , Topçu, Cemile University of Selçuk - Faculty of Meram Medicine - Department of Biochemistry, Turkey , Gürbilek, Mehmet University of Selçuk - Faculty of Meram Medicine - Department of Biochemistry, Turkey , Bariskaner, Hülagü University of Selçuk - Faculty of Selçuklu Medicine - Department of Pharmacology, Turkey , Üstün, Mehmet Erkan University of Selçuk - Faculty of Meram Medicine - Department of Neurosurgery, Turkey , Yosunkaya, Alper University of Selçuk - Faculty of Meram Medicine - Department of Anesthesiology and Intensive Care, Turkey
Abstract :
Objective: This study was designed to determine the effects of mannitol on tissue Na^+/K^+-ATPase enzyme activity and malondialdehyde (MDA) levels in rabbit brain after experimental head trauma. Methods: Thirty New Zealand rabbits were divided equally into three groups: Group S (sham-operated group), group C (untreated group) and group M (mannitol treated group). Grup C and group M received head trauma with the weight drop method. Mannitol was administered 1,0 g/ kg i.v. immediately after the head trauma to group M. Head trauma was applied to the right side of the head. One hour after trauma, brain cortices were resected from both sides and the Na^+/K^+-ATPase enzyme activity and MDA levels were determined. Results: Na^+/K^+-ATPase activities were increased and MDA levels were decreased in mannitol treated rabbits but the differences were not statistically significant (p 0,05). Conclusion: Head trauma did not cause to lipid peroxidation and any changes in Na^+/K^+-ATPase activity in brain tissue of rabbits in this model. Mannitol treatment after the trauma does not affect these parameters.
NaturalLanguageKeyword :
Mannitol , Head trauma , Na^+ , K^+ , ATPase , Malondialdehyde
