Kirdemir, Pakize Süleyman Demirel Üniversitesi - Tip Fakültesi - Anesteziyoloji ve Reanimasyon AD, Turkey , Sahin, Halil Süleyman Demirel Üniversitesi - Tip Fakültesi - Anesteziyoloji ve Reanimasyon AD, Turkey , Kaya, Selçuk Süleyman Demirel Üniversitesi - Tip Fakültesi - Tibbi Mikrobiyoloji AD, Turkey

Comparison of anti-inflammatory effect of lornoxicam, tramadol and ketamine and a their effects on acute phase protein values

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Objectives:We aimed to study, anti-inflammatory activities of lornoxicam, tramadol and ketamine in rats during acute inflammation we produced, by creating an experimental model of acute inflammation and to compare their effects on acute phase proteins (CRP, IL-1, IL-6 and TNF α). Materials and Methods: after the ethics committee approval obtained 55 Wistar-albino rats weighting between 159 gr and 208 gr were randomly allocated into four groups. Lornoxicam, tramadol and ketamine groups had 15 rats control group 10 rats. All the animals right hind paw volume was measured by test tube method. Lornoxicam group 1.3 mg / kg, tramadol group 10 mg / kg, ketamine group 10 mg / kg, 0.5 mL of saline intraperitoneally administered to the control group. After 15 min 0,1 mL carragenan was injected to the subject s hind paw of subplantar region. 3 and 6 hours after these applications, with the test tube method measurements were repeated and recorded. Also 0.5 mL blood was drawn for the values of acute phase proteins at 6. hours. Results:According control group s rat paw volumes, lornoxicam and ketamine groups had statistically significant lower values at 6th hour (p:0.004, 0.003). Compared with control group, all the groups had lower CRP, IL-1,IL-6, and TNFα values but lornoxicam and ketamine group had statistically significant low IL-1 values (0,023-0,014). Conclusions: Although lornoxicam and ketamine had lower values all three agent had effective antiiflamatory activities and they can be a good choice for postoperative pain management.

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Inflammation , lornoxicam , tramadol , ketamine , CRP , IL , 1 , IL , 6 , TNF α

Medical Journal Of Suleyman Demirel University

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