Author/Authors :
Yildiz, Mustafa Antalya Egitim ve Arastirma Hastanesi - Tibbi Onkoloji Klinigi, Turkey , Yildirim, Mustafa Antalya Egitim ve Arastirma Hastanesi - Tibbi Onkoloji Klinigi, Turkey , Parlak, Cem Antalya Eğitim ve Araştırma Hastanesi - Radyasyon Onkolojisi Kliniği, Turkey , Bülbüller, Nurullah Antalya Egitim ve Arastirma Hastanesi - 2 Genel Cerrahi Klinigi, Turkey , Eryilmaz, Ramazan Antalya Egitim ve Arastirma Hastanesi - 1 Genel Cerrahi Klinigi, Turkey , Sezer, Cem Antalya Egitim ve Arastirma Hastanesi - Patoloji Klinigi, Turkey , Yaz, Müjgan Antalya Egitim ve Arastirma Hastanesi - Patoloji Klinigi, Turkey , Süren, Dinç Antalya Egitim ve Arastirma Hastanesi - Patoloji Klinigi, Turkey , Kaya, Çetin Antalya Egitim ve Arastirma Hastanesi - Tibbi Onkoloji Klinigi, Turkey
Abstract :
Castleman disease (CD), also called as angiofollicular dysplasia, is a lymphpploriferative disease. It includes two distinct disease with different prognosis; so called multicentric and unicentric. CD is characterised by lymph node enlargement by preserving its structure. It has 3 major variant including hyaline vascular, plasma cell and mixt type. Studies about the pathogenesis of CD is mostly focused on HHV 8 (+) MCD. pathogenetic mechanisms of UCD and HHV 8 (-) MCD are unclear. CD can be misdiagnosed as malignant lesions. Herein, we discuss two cases of CD, one with unicentric hyaline variant and one with multicentric plasma cell variant nature, in the light of current literature.
