Akdogan, Mehmet Sakarya Üniversitesi - Tip Fakültesi - Biyokimya AD, Turkey , Sezer, Mehmet Tugrul Süleyman Demirel Üniversitesi - Tip Fakültesi - Iç Hastaliklari AD, Nefroloji Bölümü, Turkey , Savik, Emin Sanliurfa Çocuk Hastaliklari Hastanesi - Biyokimya Laboratuvari, Turkey , Doguç, Duygu Kumbul Süleyman Demirel Üniversitesi - Tip Fakültesi - Biyokimya AD, Turkey

The effect of renal erythropoietin on nitric oxide levels in patients with chronic renal failure

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Nitric oxide (NO) is a strong vasoactive substance which contributes to the regulation of blood pressure. One of the most frequently complications seen during haemodialysis (HD) in patients with chronic renal failure (CRF) is hypertension. It was could not explain clearly that endogen production of NO increases or decreases in this patients. Moreover, CRF causes anemia via decreasing production of renal erythropoietin (EPO). EPO is used for the treatment of anemia caused by CRF. Although the mechanism of effect of EPO is not known, it is known that it increase blood pressure. For this reason, it is planned in this study that the changes in NO levels caused by EPO in patients with CRF taking and not taking EPO. Patients with CRF (n= 17) and mean age was 45 16 year to whom HD was applied in HD unit of Isparta Government Hospital were included in this study. Systolic blood pressure and serum NO levels were determined at the beginning 0th minute (min.), 60th min., 120th min., 180th min. and at the end of the HD (240th min.). NO levels were determined by using spectrofotometric method. Statistically, significant decrease in NO levels was found at 180th and 240th min. of HD in EPO taking patients according to not taking patients with CRF(p 0.05). In conclusion; It is suggested that hypertension caused by EPO during HD may results from decreased serum NO levels.

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Blood Pressure , Hemodialysis , Nitric Oxide

Medical Journal Of Suleyman Demirel University

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