Effective molecular mechanisms of resistance to cisplatin

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Cisplatin is a platinating chemotherapeutic agent widely used in the treatment of many solid tumors. It was discovered for the first time as a growth inhibitor of Escherichia coli in 1970, later years its anticancer effects rediscovered and began to use in the treatment of testicular, ovarian, cervical, head and neck, non-small cell lung cancers and lymphoma. Although a good response to cisplatin can be achieved in the treatment of testicular cancer, therapeutic efficacy is limited due to toxicity or drug resistance in other solid tumors. In this review the molecular mechanisms trough the development of cisplatin resistance and the new treatment strategies were evaluated. Understanding the molecular mechanisms of cisplatin resistance will provides important insights for designing more efficient platinum-based chemotherapeutics.

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Cisplatin resistance , DNA damage , DNA repair , translesion synthesis , apoptosis

Medical Journal Of Suleyman Demirel University

79

Medical Journal Of Suleyman Demirel University