Ercan, Sevim Akdeniz Üniversitesi - Saglik Hizmetleri Meslek Yüksekokulu, Turkey , Koçer, Günnur Akdeniz Üniversitesi - Tip Fakültesi - Fizyoloji AD, Turkey , Çelik-Ozenci, Çiler Akdeniz Üniversitesi - Tip Fakültesi - Histoloji AD, Turkey , Gündüz, Filiz Akdeniz Üniversitesi - Tip Fakültesi - Fizyoloji AD, Turkey

Lipid peroxidation and apoptosis levels in gastric tissue of spontaneously hypertensive rats

15588

Aim: The spontaneously hypertensive rat is a widely used animal model for essential hypertension. Despite the recognized gastric complications of hypertension, such as bleeding from gastritis, gastric mucosal blood flow and motility and vascular ectasias until now no investigations have been conducted on gastric mucosal apoptosis in hypertensive animals. In this study, we investigated the lipid peroxidation and apoptotic changes in the stomachs on spontaneously hypertensive rats. Methods: Spontaneously hypertensive (n: 10) and normotensive Wistar Kyoto rats (n: 10) were used. Thiobarbituric acid reactive substances were determined as an indicator of lipid peroxidation and terminal deoxynucleotdyl transferase-mediated deoxyuridine triphosphate nick-end labelling technique was used to detect apoptosis in gastric tissue. Results: While the number of apoptotic cells were increased significantly in spontaneously hypertensive rats, thiobarbituric acid reactive substances were not changed when compared Wistar Kyoto rats. In conclusion, data presented in the current study demonstrate the significant increase in gastric mucosal apoptosis in spontaneously hypertensive rats for the first time but underlying mechanisms of apoptosis are not clarified.

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Spontaneously hypertansive rat , apoptosis , gastric tissue , lipid peroxidation

Medical Journal Of Suleyman Demirel University

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