Ceylan, Berit Gökçe Süleyman Demirel Üniversitesi - Tıp Fakultesi - Anesteziyoloji ve Reanimasyon AD, Turkey , Topal, Mehmet Süleyman Demirel Üniversitesi - Tıp Fakultesi - Anesteziyoloji ve Reanimasyon AD, Turkey , Yıldırım, Mustafa Kemal Süleyman Demirel Üniversitesi - Tıp Fakultesi - Anesteziyoloji ve Reanimasyon AD, Turkey , Osmanlıoğlu, Haci Ömer Süleyman Demirel Üniversitesi - Tıp Fakultesi - Anesteziyoloji ve Reanimasyon AD, Turkey , Eroğlu, Füsun Süleyman Demirel Üniversitesi - Tıp Fakultesi - Anesteziyoloji ve Reanimasyon AD, Turkey

Comparison of the effects of levobupivacaine and bupivacaine that administered through epidural route on peroperative and postoperative stressresponse in major lower limb surgery

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Stress response that surgical trauma induced is accepted as a pathological process. By that mean, attenuating stress response for a safe perioperative period gains importance. In this study investigating the effects of levobupivacaine and bupivacaine via epidural on preoperative and postoperative stress response was planned. Our study was performed in Suleyman Demirel University School of Medicine Department of Anaesthesiology and Reanimation in 43 ASA I-III cases that lower limb surgery has been planned. Cases were divided randomly into two groups 0,5% 15 mL levobupivacaine + 5 mL saline was administered in Group L (n=22) cases and 0,5% 15 mL bupivacaine + 5 mL saline was administered through epidural space in Grup B cases. For evaluating stress response due to surgical trauma; plasma GH, sT3, TSH, cortizol levels were investigated at the arriving to the operation room (preoperative), 30 minutes after surgical incision (peroperative) and at 24thhour after the operation (postoperative) and compared with control values. In Group L; significant increase in GH in postoperative 24th hour according to control and peroperative values (p 0,001, p=0,007) was observed; significant decrease in St3 in postoperative 24thhour according to control and peroperative values ( p 0,001, p 0,001) was observed also. In Group B; significant increase in GH in postoperative 24thhour according to control and peroperative values (p=0,003, p=0,023) and significant decrease in St3 in postoperative 24thhour according to control and peroperative values (p 0,001, p=0,002) was observed. We concluded that levobupivacaine and bupivacaine, for minimizing the stress response due to surgical trauma have no difference between each other respect to attenuation of stress response.

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Epidural anaesthesia , Bupivacaine , Levobupivacaine , Stress response

Medical Journal Of Suleyman Demirel University

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