Author/Authors :
DONDER, Emir Firat University - Faculty of Medicine - Department of Internal Medicine, Turkey , DOGAN, Murat Mehmet Sorgun State Hospital - Internal Medicine, Turkey , KULOGLU, Tuncay Firat University - Faculty of Medicine - Department of Histology and Embryology, Turkey , DABAK, Özlem Dürrin Firat University - Faculty of Medicine - Department of Histology and Embryology, Turkey , KOCAMAN, Nevin Firat University - Faculty of Medicine - Department of Histology and Embryology, Turkey , OZKAN, Yusuf Firat University - Faculty of Medicine - Department of Internal Medicine, Turkey
Abstract :
Objective: The aim of this study was to examine the effects of enalapril and losartan on ghrelin immunoreactivity in the kidney tissues of rats with streptozotocin (STZ) induced diabetes. Materials and Methods: The study involved 28 Wistar albino rats. The rats were allocated to four groups: control group (n=7), diabetes (DM) group (n=7), DM + enalapril group (n=7) and DM + losartan group (n=7). DM, DM + enalapril and DM + losartan groups were administered a single dose of 50 mg/kg of STZ, intraperitoneally. The rats in the treatment groups were orally administered 5 mg/kg/day of enalapril and 10 mg/kg/day of losar-tan, starting with the onset of diabetes. At the end of the fourth week of the experiment, rats were decapitated. Kidney tissues collected from the animals were processed by using routine histological techniques. Ghrelin immunoreactivity was determined by avidin biotin-peroxidase method. Results: Ghrelin immunoreactivity in the distal tubules was moderate (++) in the control group and severe (+++) in the diabetic group. In the distal tubules of the treatment groups, ghrelin immunoreactivity was observed to be moderate ( +), similar to the control group. Conclusion: It was determined that enalapril and losartan were effective against ghrelin immunoreactivity in the diabetic rat kidney tissues.
NaturalLanguageKeyword :
Diabetes mellitus , Enalapril , Losartan , Ghrelin
