EROL, Fatih Serhat Firat University - Faculty of Medicine - Department of Neurosurgery, Turkey , ÖZTÜRK, Mehmet Birol Fırat University - Faculty of Medicine - Department of Neurosurgery, Turkey , AKGÜN, Bekir Fırat University - Faculty of Medicine - Department of Neurosurgery, Turkey , KAPLAN, Metin Firat University - Faculty of Medicine - Department of Neurosurgery, Turkey , ÇAKIN, Hakan Fırat University - Faculty of Medicine - Department of Neurosurgery, Turkey , İLHAN, Necip Firat University - School of Medicine - Department of Biochemistry, Turkey , SERHATLIOĞLU, Selami Fırat University - Faculty of Medicine - Department of Radiology, Turkey

Correlation Between Findings of Cranial Tomography and the Levels of Cerebrospinal Fluid’s Nerve Growth Factor in Hydrocephalic Infants

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Objective: To investigate the correlation between the NGF levels in the CSF and brain tomography indexes in preoperative and postoperative evaluations of hydrocephalic infants undergoing ventriculoperitoneal shunt. Material and Method: A total of 27 patients were included. CSF samples were obtained in the during the operation and on the 3rd and 30th postoperative days, and CT evaluations were performed. Results: No correlation was found between the NGF levels in CSF and CCT indexes using the Spearman correlation. The increases of NGF levels on the 3rd postoperative day were significantly higher than those of the peroperative levels (p 0.05). While the decrease was significant between the levels of NGF on the 30th and the 3rd postoperative days (p 0.05), the difference was not significant between the levels on the 30th postoperative day and the levels in the peroperative period (p 0.05),(0,023/0,015). The differences between the postoperative 3rd and 30th days were significant according to Evan’s indexes, 3th ventricle indexes and ventricular scores (p 0.05). It was found that there was no significant difference between Sella media indexes in the preoperative period and on the postoperative 3rd day (p 0.05), (0,48/0,44), but that there was significant decrease on the 30th postoperative day (p 0.05). Conclusion: Conclusions:There was no significant correlation between NGF levels of CSF and brain tomography indexes in the preoperative and postoperative evaluation of infants with hydrocephaly. However, significant relationship was seen within each parameter. The NGF levels of CSF and cranial tomography indexes can be helpful in the diagnosis, treatment and follow-up of hydrocephalus.

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Cerebrospinal fluid , Computerized cranial tomography , Hydrocephalus , Nerve growth factor.

Fırat Medical Journal

150