KILIÇ, Mehmet Fırat Üniversitesi - Tıp Fakültesi - Çocuk Allerji-İmmunoloji Bilim Dalı, Türkiye , TAŞKIN, Erdal Fırat Üniversitesi - Tıp Fakültesi - Neonatoloji Bilim Dalı, Türkiye , SELMANOĞLU, Ahmet Fırat Üniversitesi - Tıp Fakültesi - Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Türkiye

The Retrospective Evaluation of Children with Primary Immunodeficiency Disease

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Objective: In this study, we aimed to investigate of clinical and demographic characteristics in children with the diagnosis of primary immunodeficiency our clinic. Material and Method: The medical records of 78 patients with primary immunodeficiency who are followed by department of pediatric immunology and allergy between February 2008 and March 2014 were evaluated retrospectively. Results: 61.5% (n=48) of the patients were boys and 38.5% (n=30) were girls. The mean age at the diagnosis was 5.4 ± 4.0 (0.4-19) years, the mean age at the beginning of symptoms was 3.0 ± 2.9 (0.1-15) years. The clinical presentations were lower respiratory tract infections 65.4% (n=51), upper respiratory tract infections 55.1% (n=43), gastroenteritis 16.7% (n=13), oral candidiasis 9% (n=7), recurrent urinary tract infections 6.4% (n=5), and eczema 6.4% (n=5), respectively. 71.8% of patients (n=56) had immunodeficiency due to antibody deficiency. The ratios of the other immunodeficiencies were other well-defined immunodeficiency syndromes 10.3% (n=8), severe combined immunodeficiency 7.7% (n=6), other immune deficiencies 3.8% (n=3), complement deficiency 3.8% (n=3), and defects of phagocytic system 1.3 % (n=1). Conclusion: The incidence of primary immunodeficiency is high in our country, due to the high rate of consanguineous marriages. We thought that physician must becareful in terms of early diagnosis and treatment is necessary for reducing the complications due to immune deficiency.

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Children , İmmundeficiency , Antibody deficiency

Fırat Medical Journal

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