The Effects of Statins on Testicular Ischemia Reperfusion-Induced Histopathologic Injury

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Objective: Testicular torsion is a common syndrome that could lead to infertility. This study was designed to evaluate the histopathological effects of single dose of statins which have different pharmacological properties, in testicular ischemia/ reperfusion (IR) injury model that resembles testicular torsion/detorsion. Material and Methods: Rats were anesthetized with intraperitoneal (i.p.) thiopental sodium (50 mg/kg) before the operation. Left testicular artery and vein of rats were occluded for 1 hour and the organ was allowed to reperfuse 24 hour before the orchiectomy for histologic examination. Simvastatin (5 mg/kg, i.p.), pravastatin (5 mg/kg, i.p.), atorvastatin (10 mg/kg, i.p.) or vehicle (10 % dimethylsulfoxide) was administrated before reperfusion. Results: IR caused a significant histopathologic damage of left testis. The mean Johnsen score in IR group was lower than sham group (p=0.001). The score of testes treated with simvastatin was lower than sham (p=0.001) but higher than IR group (p=0.004). Atorvastatin and pravastatin treatments did not alter the mean Johnsen score. Conclusion: The present study showed that simvastatin treatment reduced IR induced histopathologic injury, while atorvastatin and pravastatin did not alter. In conclusion, we thought that these different effects of statins may be dependent on their different chemical and pharmacological properties.

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Simvastatin , pravastatin , atorvastatin , ischemia , reperfusion injury , testis

Fırat University Medical Journal Of Health Sciences

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Fırat University Medical Journal Of Health Sciences