مرکز منطقه ای اطلاع رساني علوم و فناوري - Determination of the Relationships Between Effectiveness of Short and Long Term Treatment of Major Depressive Disorders and Nesfatin-1, Ghrelin and Nitric Oxide Levels

Abstract :

Objective: The major depressive disorder (MDD) is a serious mental disease reducing the quality of life. Its prevalence is increasing in developed and developing countries. In the present study, to understand the relationships between MDD and hormonal changes, we were purposed to examine the nesfatin-1, nitric oxide and ghrelin levels before and after the 9 months of treatment. Materials and Methods: Total of 60 subjects (30 MDD 39.8±2 yr, 64.9±1.8 kg; 30 healthy control 36.6±3 yr 70.6±2.3 kg). Fasting venous blood samples were taken three times: At the basal, at the end of the three and nine months of the study. ELISA method was used to analyse serum nesfatin-1, nitric oxide and ghrelin levels. Results The basal nesfatin-1 level in MDD was found to be significantly higher (73.4±1.3 ng/mL) than the control levels (13.5±3.2 ng/mL) (P=0.001). However, it decreased significantly to 37.6±4.3 ng/mL after 3 months (P=0.001) and 22.3 ±3.5 ng/mL after 9 months (P=0.001). The basal NO level in MDD (2.7±0.6 nmol/L) was found to be significantly lower than the control (6.5±0.4 nmol/L) (P=0.001). It increased to 3.5±0.7 nmol/L in the first third month (P=0.04) and continued to increase after 9 months 4.1±0.9 nmol/L (P=0.04). In the MDD, basal ghrelin level (44.5±3.7 pg/mL) was found to be significantly lower than the control (310.3±35.6 pg/mL) (P=0.001) but it did not change significantly after 3 (42.5±3.7 pg/mL) and 9 months (40.8±2.6 pg/mL) of the study. Conclusion: Observation of the markedly high nesfatin-1 and markedly low NO levels at the basal and significant decrease in nesfatin-1 and increase in NO levels to their control level after treatment may be help to understand the patients current status. Further studies are needed to understand this relationship between MDD and nesfatin-1 and NO levels