Author/Authors :
kiliç, nuh adnan menderes üniversitesi - veteriner fakültesi - cerrahi anabilim dalı, Turkey , kozaci, l. didem yıldırım beyazıt üniversitesi - tıp fakültesi - tıbbi biyokimya anabilim dalı, Turkey
Title Of Article :
Effects of Flunixine Meglumine, Diclofenac Sodium, Metamizol Sodium and Carprofen on Oxidative Stress in Rats Subjected to Laparotomy
Abstract :
The aim of this study was to determine the effects of nonsteroid antiinflammatory drugs on oxidative stress in rats subjected to laparotomy. Rats (n=50) were divided into five equal groups. Control group (n=10, Group I) received physiological saline whereas Groups II-V (n=10 in each) received metamizole (50 mg/kg), flunixin meglumine (2.5 mg/kg), carprofen (2.5 mg/kg), or diclofenac (2.5 mg/kg) by intraperitoneal injection for 5 days following the operation. On postoperative day 6, blood samples were obtained; levels of malondialdehyde (MDA) and nitric oxide (NO) in serum, and erythrocyte glutathione (GSH), catalase levels were determined. NSAIDs caused a decrease in MDA, NO and GSH levels, whereas catalase levels increased with NSAID treatment. In conclusion, NSAIDs may have additional beneficial effects to their anti-inflammatory effects by diminishing the oxidative stress.
NaturalLanguageKeyword :
Oxidative stress , laparotomy , NSAIDs , rat
JournalTitle :
Fırat University Veterinary Journal Of Health Sciences
