çeribaşi, ali osman fırat üniversitesi - veteriner fakültesi - patoloji anabilim dalı, Elazığ, TURKEY , güvenç, mehmet mustafa kemal üniversitesi - veteriner fakültesi - fizyoloji anabilim dalı, Hatay, TURKEY

Protective Effects of Pomegranate Juice and Cinnamon (Cinnamomum Zeylanicum) Bark Oil on Carbon Tetrachloride-Induced Chronic Liver Damage in Rats

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The aim of this study was to investigate the probable hepatoprotective effects of pomegranate juice (PJ) and cinnamon bark oil (CBO) ingestion on carbon tetrachloride (CCl4)-induced chronic damages in liver tissues of rats. The study comprised of six treatment groups as control, PJ, CBO, CCl4, CCl4+PJ and CCl4+CBO. All administrations were done by gavage. The administration doses of PJ, CBO and CCl4 were 5 mL/kg/day, 100 mg/kg/day, and 0.25 mL/kg/week, respectively. CCl4 treatment caused a significant increase in the liver malondialdehyde (MDA) level, apoptotic cell index, and a significant decrease in the antioxidant markers along with severe lesions. Both PJ and CBO administrations to the CCl4-treated rats significantly increased the antioxidant markers, and significantly decreased the MDA level, apoptotic cell index and the severity of all hepatic lesions except bile duct hyperplasia, hydropic degeneration and periportal cell infiltrations. The results of this study demonstrate that PJ and CBO are effective for the prevention of CCl4-induced hepatic damage in rats. The hepatoprotective effects of PJ and CBO are possibly due to the reductions in liver fibrogenesis and apoptosis associated with the prevention of CCl4-induced oxidative stress.

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Apoptosis , carbon tetrachloride , cinnamon bark oil , lipid peroxidation , pomegranate juice

Fırat University Veterinary Journal Of Health Sciences

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