Author/Authors :
ELİTOK, Bülent Afyon Kocatepe University - Faculty of Veterinary Medicine - Department of Internal Medicine, TURKEY
Abstract :
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient without a history of alcohol abuse. Nonalcoholic fatty liver disease (NAFLD) is characterized by a wide range of liver damage spanning steatosis, nonalcoholic steatohepatitis (NASH), cryptogenic liver cirrhosis, and even to hepatocellular carcinoma. The pathogenesis of NASH is multifactorial, with insulin resistance and increased fatty acid are possibly important factors in the accumulation of hepatocellular fat, and oxidative stress, lipid peroxidation, mitochondrial dysfunction, and dysregulation of various cytokines are important causes of hepatocellular injury in steatotic liver. Herbal remedies have long been used in treating liver inflammation and other symptoms associated with fatty liver disease, although more clinical research evidence may be necessary to determine these supplements true effectiveness and mechanisms of action. In this review, we tried to describe the characteristics and current treatments of NAFLD and provide opportunities for developing new therapeutic management approaches, with particular emphasis on development of animal studies.
