مرکز منطقه ای اطلاع رساني علوم و فناوري - The Time Dependent Effects of Intravenous Administration of Isotonic Sodium Bicarbonate On Venous Acid-Base Status and Renal Function In Neonatal Calves with Acute Diarrhea

Abstract :

This study investigates time-dependent effects of intravenous administration of isotonic sodium bicarbonate on venous acid-base status and renal function in neonatal calves with acute diarrhea. The etiologic diagnosis was not taken into consideration in this study. The material consists of 10 neonatal calves (1-30 days old) which were accepted to the clinic with complaints of acute diarrhea. Following the intravenous administration of calculated total sodium bicarbonate on the calves in the form of isotonic solution blood samples were collected pre-treatment and post-treatment: 15th min, 30th min, 1st hrs, 2nd hrs, 3rd hrs, 4th hrs, 6th hrs, 12th hrs and 24th hrs later. Based on the intra- group assessments at different measurement times, the study results revealed a statistically significant difference in pH, bicarbonate (HCO3-), basicity (BE), partial carbondioxide pressure (PCO2), total carbondioxide concentration (TCO2), potassium (K^+) and AST blood levels of the calves with diarrhea. A numerical decrease was determined in the post-treatment period despite the absence of a significant difference in serum concentrations of urea and creatinine as shown by the intra-group statistical assessments conducted in line with measurement times. The obtained data revealed that primary simple metabolic acidosis occurring in calves in relation to acute diarrhea can be treated successfully with the administration of intravenous isotonic sodium bicarbonate. According to the results, renal function deterioration should be considered along with the metabolic acidosis during the determination of treatment protocol and prognosis. The submitted study emphasizes the importance of hours 12 and 24 post-treatment for blood acid-basis status and renal function, respectively.