Author/Authors :
KASAPÇOPUR ÖZEL, Gülsüm Sinem Afyon Kocatepe Üniversitesi - Veteriner Fakültesi - Farmakoloji ve Toksikoloji A D, Turkey , BİRDANE, Yavuz Osman Afyon Kocatepe Üniversitesi - Veteriner Fakültesi - Farmakoloji ve Toksikoloji A D, Turkey
Abstract :
Free radicals are very harmful radicals that give damage to DNA, lipids, proteins in living organisms. The endogenous sources of radicals are mitochondrial electron transport, phagocytosis, arachidonic acid metabolism, enzyme reactions. Radiation, cigarette smoke, ozone, UV light, chemicals, drugs, metals are the exogenous sources of radicals. Free radicals can be harmless by the defence of organism called antioxidant defence. In sometimes the equilibrium between radicals and antioxidant defence system can breakdown. At this time radicals give harm to tissues and oxidative stress occurs.A lots of diseases occurs by oxidative stress like cancer, atherosclerosis, hypertension, asthma, diabetes mellitus, Alzheimer, Parkinson, rheumatoid arthritis,etc. Endogenous and exogenous antioxidants can be used in prophylaxis and therapy. The importance of E, C and A vitamins, flavonoids, lycopen, trace elements, thiol compounds increases as a antioxidant.
