küçükkurt, ismail afyon kocatepe üniversitesi - veteriner fakültesi - biyokimya anabilim dalı, Turkey , arslan-acaröz, damla afyon kocatepe üniversitesi - veteriner fakültesi - biyokimya anabilim dalı, turkey , demirel, hasan hüseyin afyon kocatepe üniversitesi - bayat meslek yüksekokulu - laborant ve veteriner sağlık bölümü, Turkey , ince, sinan afyon kocatepe üniversitesi - veteriner fakültesi - farmakoloji ve toksikoloji anabilim dalı, Turkey , eryavuz, abdullah afyon kocatepe üniversitesi - veteriner fakültesi - fizyoloji anabilim dalı, Turkey

Potential Protective Effect of Boron Against Gentamicin-Induced Oxidative Stress on Rat Tissues

18392

The objective of this study was to determine the protective effects of boron on gentamicin induced toxicity in rats. Rats were divided into eight experimental groups containing seven animals in each group. Experimental groups were as follows; control group (fed without B), gentamicin group (100 mg/kg, i.p.), B-5 group (5 mg/kg B, i.p.), B-10 group (10 mg/kg B, i.p.), B-20 group (20 mg/kg B, i.p.), B-5 + gentamicin group (5 mg/kg B and 100 mg/kg gentamicin, i.p.), B-10 + gentamicin group (10 mg/kg B and 100 mg/kg gentamicin, i.p.), and B-20 + gentamicin group (20 mg/kg B and 100 mg/kg gentamicin, i.p.). B was given to rats before four days. Gentamicin was given to rats on the fourth day and finished on the twelfth day. Also, administration of B was completed the fourteenth day. End of the experiment, liver, hearth, brain, lung, and testis tissues were collected from animals under anaesthesia. Administration of gentamicin increased malondialdehyde levels whereas decreased reduce glutathione levels, superoxide dismutase and catalase activities in the liver. Histopathologically, damages were detected in the tissues of gentamicin group. However, treatment of boron resulted in a reversal of gentamicin-induced damages.

172

Boron , Gentamicin , Histopathology , Lipid Peroxidation , Oxidative Stress , Rat

Kocatepe Veterinary Journal

179