مرکز منطقه ای اطلاع رساني علوم و فناوري - The Effects of Amoxicillin Clavulanic Acid, Amoxicillin Clavulanic Acid + Vitamin Administration on Malondialdehyde and Antioxidant Levels in Kidney and Liver Tissues of the Rats

Abstract :

It is aimed to investigate the effects of Amoxicillin Clavulanic Acid (AKA) and vitamins on antioxidants and oxidative stress in liver and kidney tissues of the rats. 49 Wistar-albino male rats were divided into seven groups. We applied; group1: AKA, group2: AKA+vitamin C, group3: AKA +vitamin E, group4: AKA+vitamin C+vitamin E, group5: vitamin C, group6: vitamin E and group7: as a control group. At the end of the study Malondialdehyde(MDA), reduced glutathione(GSH), catalase activities(CAT), vitaminC, total protein levels in liver and kidney tissues of the rats were analyzed, and plasma ALT, AST and GGT levels were measured. The ALT increased significantly in Group1(p 0.001). Renal tissue MDA increased in only group1(p 0.05). A significant decrease was determined in GSH levels in group2 and 4(p 0,05). CAT showed a significant increase in group1 (p 0.01) and a decrease in group4(p 0.05). Group6 showed an increase in CAT activity(p 0.01). Renal tissue vitaminC was significantly lower in group1(p 0.001). Liver tissue MDA were increased in all groups(1., 3. and 5. groups p 0.05; 2., 4. and 6. groups p 0.01). GSH decreased in only group4(p 0.01). CAT activities decreased significantly in all other groups (group1 and 2; p 0.01, group6; p 0.05). VitaminC decreased in group1(p 0.001) and group2(p 0.01) significantly. Total protein in liver tissue decreased only in group4(p 0.001). Changes in parameters suggest that there may be oxidative damage-induced degenerations in liver and kidney cells. As a result, it has come to the conclusion that it may be useful to use antioxidants in addition to antibiotics against oxidative damage.