Author/Authors :
el haber, carla university hospital hôtel-dieu de france - department of pediatrics, Beirut, Lebanon , torbey, paul henry university hospital hôtel-dieu de france - department of pediatric oncology, department of pediatrics, Beirut, Lebanon
Title Of Article :
OSSEOUS INVOLVEMENT OF LANGERHANS CELL HISTIOCYTOSIS IN CHILDHOOD Case Reports
Abstract :
Langerhans cell histiocytosis (LCH) is a rare disease arising from clonal proliferation of Langerhans cells, affecting predominantly children. It can take many forms, from a single eosinophilic granuloma to widespread lesions involving multiple systems and might be life-threatening. Bone is the most common organ involved; osseous involvement can be uni- or multifocal. We report two cases : a multifocal osseous Langerhans cell histiocytosis involving the 9th left rib, vertebral body of T1 and the left iliac bone; and a unifocal osseous Langerhans cell histiocytosis involving the right femur. Biopsy established the diagnosis in correlation with radiology. The patients received chemotherapy and steroids. Outcome wasfavorable on follow-up.
NaturalLanguageKeyword :
Langerhans cell histiocytosis , eosinophilic granuloma
JournalTitle :
Lebanese Medical Journal
