Author/Authors :
abou hamad, walid saint joseph university - hôtel dieu de france university hospital (hdf), faculty of medicine - department of otolaryngology head and neck surgery, Beirut, Lebanon , khoueir, nadim saint joseph university - hôtel- dieu de france university hospital (hdf), faculty of medicine - department of otolaryngology head and neck surgery, Beirut, Lebanon , assily, ralph saint joseph university - hôtel-dieu de france university hospital (hdf), faculty of medicine - department of otolaryngology head and neck surgery, Beirut, Lebanon , nassereddine, hussein hôtel-dieu de france university hospital (hdf) - department of pathology, Beirut, Lebanon , rassy, marc hôtel-dieu de france university hospital (hdf) - department of pathology, Beirut, Lebanon , ghorra, claude hôtel-dieu de france university hospital (hdf) - department of pathology, Beirut, Lebanon
Abstract :
Introduction: The classification of chronic rhinosinusitis with nasal polyposis (CRSwNP) into eosinophilic and non-eosinophilic has prognostic and therapeutic implications. It was never reported in a Middle Eastern population. Methods: Retrospective study in a tertiary care center located in Lebanon. Records of 76 patients with CRSwNP treated by endoscopic sinus surgery were reviewed. Two pathologists independently counted the number of eosinophils and neutrophils in the three fields containing the greatest degree of cellular infiltration. Eosinophilic CRSwNP was defined by five or more eosinophils per high-power field. Results : The mean number of eosinophils and neutrophils in the population were respectively 106 and 10 per high-power field. Sixty-eight patients (89.5%) had eosinophilic CRSwNP while eight (10.5%) had non-eosinophilic CRSwNP. In the asthmatic subgroup (14.5%), all patients had an eosinophilic profile. The proportion of eosinophilic CRSwNP in the nonasthmatic subgroup was 88%. The interobserver agreement between the two pathologists was very good. Conclusion : The majority of the studied population had an esosinophilic CRSwNP. The histopathological profile of CRSwNP in a Middle Eastern population seems to be similar to the reported profile of Western populations.
NaturalLanguageKeyword :
chronic rhinosinusitis , polyposis , eosinophils , neutrophils
