Giray, Belma Hacettepe Üniversitesi - Eczacılık Fakültesi - Farmasötik Toksikoloji Anabilim Dalı, Turkey , Erkekoglu, Pinar Hacettepe Üniversitesi - Eczacılık Fakültesi - Farmasötik Toksikoloji Anabilim Dalı, Turkey , Sabuncuoglu, Suna Hacettepe Üniversitesi - Eczacılık Fakültesi - Farmasötik Toksikoloji Anabilim Dalı, Turkey , Aydin, Sevtap Hacettepe Üniversitesi - Eczacılık Fakültesi - Farmasötik Toksikoloji Anabilim Dalı, Turkey , Sahin, Gönül Hacettepe Üniversitesi - Eczacilik Fakültesi - Farmasötik Toksikoloji Anabilim Dali, Turkey

Serum Ochratoxin A Levels in Geriatric Population

18710

Ochratoxin A (OTA) is one of the most abundant food-contaminating mycotoxins. It is nephrotoxic to all animal species studied and also immunosuppressive, hepatotoxic, teratogenic and genotoxic. There is limited number of studies on the levels of OTA in humans. The aim of this study was to determine serum levels of OTA in geriatric population as well as to establish its relation with sex, feeding habits and body mass index. Serum OTA levels were measured by enzyme immunoassay in geriatric study group (mean age: 72.8 ± 5.6, n=30) living in Mediterranean and Central Anatolia regions. We found that the mean OTA level in women (0.601 ± 0.012 ng/ml) was higher (approximately 2 fold) than in men (0.453 ± 0.078 ng/ml) (p 0.05). Serum OTA levels in Central Anatolia were found to be higher than Mediterranean Region (2.5 fold) (p 0.05) possibly due to feeding habit differences between the sexes and regions. On the other hand, daily intake levels of OTA in all study groups were calculated below the tolerable daily intake levels approved by regulatory authorities. It can be considered that the exposure to different mycotoxins along with OTA can cause synergistic or additive effects particularly in geriatric population.

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Geriatric population , ochratoxin A , nephrotoxicity , ELISA , Turkey

Journal of Research in Pharmacy

74