Author/Authors
Alpan, Ayşe Selcen Ege Üniversitesi - Eczacılık Fakültesi - Farmasötik Kimya Anabilim Dalı, Turkey , Yılmaz, Övgü Ege Üniversitesi - Eczacılık Fakültesi - Analitik Kimya Anabilim Dalı, Turkey , Kılıçkaya, Ozan Ege Üniversitesi - Eczacılık Fakültesi - Analitik Kimya Anabilim Dalı, Turkey , Kara, Pınar Ege Üniversitesi - Eczacılık Fakültesi - Analitik Kimya Anabilim Dalı, Turkey , Güneş, Hasan Semih Ege Üniversitesi - Eczacılık Fakültesi - Farmasötik Kimya Anabilim Dalı, Turkey , Özsöz, Mehmet Şengün Ege Üniversitesi - Eczacılık Fakültesi - Analitik Kimya Anabilim Dalı, Turkey
Title Of Article
Synthesis and voltammetric detection of 1H-benzimidazole derivatives on the interaction with DNA
شماره ركورد
18725
Abstract
In this study, synthesis and determination of interaction between DNA and 1Hbenzimidazole derivatives has been performed by using electrochemical genosensor technology. Detection of DNA – drug interaction mechanism relies on monitoring Differential pulse voltammetric (DPV) responses of drugs at disposable graphite electrodes (DGEs). Interaction of 7 different benzimidazole derivates between double-stranded (ds) and singlestranded (ss) DNA were observed by changing the voltammetric signals of drugs at the detection limits of 0.62 nM of compound 1, 1.23 nM of 2, 1.26 nM of 3, 1.08 nM of 4, 1.13 nM of 5, 0.69 nM of 6 and 0.42 nM of 7, respectively.
From Page
48
NaturalLanguageKeyword
1H , benzimidazole , electrochemical genosensor , DNA , drug interaction , synthesis
JournalTitle
Journal of Research in Pharmacy
To Page
55
JournalTitle
Journal of Research in Pharmacy
Link To Document