Author/Authors :
Gündoğdu, Evren Atlihan Ege University - Faculty of Pharmacy - Department of Biopharmaceutics and Pharmacokinetics, Turkey , Kırılmaz, Levent Ege University - Faculty of Pharmacy - Department of Biopharmaceutics and Pharmacokinetics, Turkey
Title Of Article :
An approach to the intelligent drug delivery systems: Thermo-responsive membrane for pulsatile drug delivery
Abstract :
In this study, the potential use of thermotropic liquid crystals as a responsive release system was investigated. Cholesteryl oleyl carbonate liquid crystal (COC) has been embedded in nylon membranes by using vacuum filtration methods. In vitro drug release studies were performed by using a fluid/fluid diffusion cell. Sodium salicylate as a model drug penetration study was performed in nylon membrane with or without COC that is prepared at 25 and 37°C. Also the penetration studies were performed by repeatedly exchanging the temperature cycle (10, 25, 37°C) of the water bath at predetermined intervals. It was observed that COC and temperature have effects on the penetration of sodium salicylate. At 37 °C, the penetration rate of sodium salicylate was found higher than 25 °C and 10 °C, respectively. Also, the penetration amount of sodium salicylate has changed as pulsatile drug delivery in the presence of COC. As a result, according to the patients’ requirements, it seems that the penetration rate and profile can be adjusted by developing pulsatile drug delivery as a new system.
NaturalLanguageKeyword :
Cholesteryl oleyl carbonate , nylon membrane , pulsatile drug delivery , sodium salicylate
JournalTitle :
Journal of Research in Pharmacy
