Author/Authors
Türk, Gaffari Firat Üniversitesi - Veteriner Fakültesi - Dölerme ve Suni Tohumlama Anabilim Dali, Turkey
Title Of Article
Adverse effects of chemotherapeutics on male reproductive system, and protective strategies
شماره ركورد
18763
Abstract
Although cytotoxic chemotherapy is an effective method for the treatment of many cancer types, it causes numerous adverse effects on the body. Infertility is also one of the most prominent side effects of chemotherapeutic drugs on both females and males. Impotence, oligo-, azoo-, asthenozoo- and teratozoo-spermia, disturbances in testicular structure, spermatogenesis and steroidogenesis, the changes in gonadotrophin levels, damages in sperm DNA and chromosomes, and even exact sterility are the reported side effects induced by chemotherapy in both males with cancer and healthy experimental animals. To prevent the gonadotoxic effects of chemotherapeutics in males, several modalities such as hormone and antioxidant administrations, sperm and germ cell cryopreservation are used. In this review, the data about the adverse effects induced by chemotherapeutics, which are commonly used in cancer treatment, in reproductive organ, tissue and cells in both males with cancer and healthy experimental animals and, also knowledge related to the preventive or protective strategies against these side effects are presented.
From Page
73
NaturalLanguageKeyword
Antioxidant , chemotherapeutics , cryopreservation , oxidative stress , sperm , testis
JournalTitle
Journal of Research in Pharmacy
To Page
92
JournalTitle
Journal of Research in Pharmacy
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