Author/Authors :
AKDAG, Kadriye Marmara University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , KOCYIGIT-KAYMAKCIOGLU, Bedia Marmara University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Turkey , TABANCA, Nurhayat University of Mississippi - Center for Natural Products Research, USA , ALI, Abbas University of Mississippi - Center for Natural Products Research, USA , ESTEP, Alden United States Department of Agriculture (USDA) - Center for Medical, Agricultural and Veterinary Entomology (CMAVE) - Agricultural Research Service (ARS), USA , BECNEL, James J. United States Department of Agriculture (USDA) - Center for Medical, Agricultural and Veterinary Entomology (CMAVE) - Agricultural Research Service (ARS), USA , KHAN, Ikhlas A. University of Mississippi - Center for Natural Products Research, USA
Abstract :
A series of novel hydrazide-hydrazone derivatives were synthesized and evaluated for their larvicidal and adult topical activity against Aedes aegypti. The proposed structures of all the synthesized compounds were confirmed using elemental analysis, UV, IR, 1H-NMR, 13C-NMR and mass spectroscopy. Compounds 4a-h were screened in larval bioassays at concentrations of 100, 50 and 25 ppm in a dose dependent manner and data for their mortality was recorded. Among the tested compounds, 1-(4-nitrophenyl)-3-(4-{2- oxo-2-[2-(2-oxo-1,2-dihydro-3H-ylidene)hydrazinyl] ethyl} phenyl)urea (4b) showed noteworthy larvacidal activity against Aedes aegypti. Dose-response data of compound 4b showed LC50 and LC90 values of 30.5 (15.4 – 22.7) and 95.9 (73.8 – 139.4) ppm, respectively. Screening of compounds 4a-h at four doses by topical bioassay indicated a range of activity between 10000 and 1000 ppm.
NaturalLanguageKeyword :
Hydrazide , hydrazone , mosquito control , Aedes aegypti , larvicidal activity , adult topical activity
