مرکز منطقه ای اطلاع رساني علوم و فناوري - The effects of bitter almond oil on some biochemical parameters in serum and erythrocytes of streptozotocin-induced Type-1 diabetic rats

Abstract :

The present study was designed to evaluate the efficacy of bitter almond oil on some biochemical parameters in serum and erythrocytes of streptozotocin-induc ed type-1diabetic rats. The rats were divided into three groups: Control (C); Diabetes (STZ); Diabetes+Bitter almond oil (STZ+BAO). Experimental diabetes induced in rats with a single intraperitoneal streptozotocin injection (65 mg/kg). 1 ml/kg dose of bitter almond oil was intraperitoneally injected to bitter almond oil group rats (STZ+BAO) twice in a week and additionally 2 g/500 ml dose of bitter almond seed powder was added to the drinking water of these rats. According to control group, postprandial blood glucose level was significantly increased (p 0.001) in the STZ group; but its level was significantly decreased (p 0.001) in the STZ+BAO group when compared to the STZ group. Malondialdehyde (MDA) levels of serum and erythrocytes increased significantly (p 0.001) in STZ group and glutathione (GSH) level erythrocytes decreased significantly (p 0.001) when compared to control group. It was detected that, MDA levels of serum and erythrocytes significantly decreased (p 0.001) in the STZ+BAO group and GSH levels were significantly (p 0.001) inreased compared to STZ group. In the serum, the palmitic and linoleic acid levels; in the erythrocytes, the palmitic, palmitoleic, stearic, arachidonic and docosahexaenoic acid levels were closed to the control group values in the STZ+BAO group. In also, in the serum, α-tocopherol acetate and β-sitosterol levels; in the erythrocytes, α-tocopherol levels were closed to the control group values in the same group. The α-tocopherol level was increased in the serum of STZ+BAO group when comparison to the STZ group. In conclusion, it was determined that the treatment of bitter almond oil positively affected lipid peroxidation, glutathione, fatty acids and α-tocopherol levels in the serum and erythrocytes of diabetic rats. According to our study results, bitter almond oil consumption could be a good diet strategy in the treatment of diabetes, but these results should be supported by detail researchs.