Altınova, Alev Eroğlu Gazi Üniversitesi - Tıp Fakültesi - Endokrinoloji ve Metabolizma BD, Turkey , Aktürk, Müjde Gazi Üniversitesi - Tıp Fakültesi - Endokrinoloji ve Metabolizma BD, Turkey , Törüner, Füsun Gazi Üniversitesi - Tıp Fakültesi - Endokrinoloji ve Metabolizma BD, Turkey , Kaya, Meral Gazi Üniversitesi - Tıp Fakültesi - İç Hastalıkları ABD, Turkey , Bukan, Neslihan Gazi Üniversitesi - Tıp Fakültesi - Biyokimya ABD, Turkey , Yetkin, İlhan Gazi Üniversitesi - Tıp Fakültesi - Endokrinoloji ve Metabolizma BD, Turkey , Çakır, Nuri Gazi Üniversitesi - Tıp Fakültesi - Endokrinoloji ve Metabolizma BD, Turkey , Arslan, Metin Gazi Üniversitesi - Tıp Fakültesi - Endokrinoloji ve Metabolizma BD, Turkey

THE PREVALENCE OF VITAMIN D DEFICIENCY AND ITS RELATIONSHIP WITH CRP, FIBRINOGEN, GLYCEMIC CONTROL AND INSULIN RESISTANCE IN PATIENTS WITH TYPER DIABETES

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Aim: We aimed to investigate the prevalence of 25-hydroxyvitamin D deficiency and the effect of vitamin D deficiency on sensitive C-reactive protein (CRP), fibrinogen, lipid, lipoprotein levels, glycemic control and insulin resistance in patients with type 2 diabetes mellitus (DM). Methods: A total of 132 patients (79 women and 53 men) were enrolled the study. Results: Vitamin D deficiency was found in 37.9% of the patients (53.2% in women and 15.1% in men). The frequency of vitamin D deficiency in obese female patients wearing covered dress was 71.9%. Female patients who are vitamin D deficient had increased BMI, PTH and decreased apolipoprotein A and HDL cholesterol levels compared to vitamin D sufficient female patients. But CRP, fibrinogen, blood glucose, HbA1c levels and HOMA-IR were not different in these two groups. The measured parameters were comparable between male patients with and without vitamin D deficiency. In whole group, vitamin D correlated negatively with BMI, HOMA-IR, PTH, ALP and positively with creatinine. Conclusion: In our study, we observed increased prevalence of vitamin D deficiency in patients with type 2 DM, especially in obese female patients wearing covered dress. While there was an association between vitamin D and insulin resistance, there was no effect of vitamin D deficiency on CRP, fibrinogen and glycemic control.

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Type 2 Diabetes , Vitamin D , Glycemic Control , Insulin Resistance , CRP , Fibrinogen

Gazi Medical Journal

120