Author/Authors :
Yılmaz, Tonguç Utku Gazi Üniversitesi - Transplantation Unit, Turkey , Sözen, Hakan Gazi Üniversitesi - Transplantation Unit, Turkey , Kılıç, Koray Gazi Üniversitesi - Faculty of Medicine - Department of Radiology, Turkey , Erbaş, Gonca Gazi Üniversitesi - Faculty of Medicine - Department of Radiology, Turkey , Cesur, Nesibe Gazi Üniversitesi - Faculty of Medicine - Department of Pathology, Turkey , Dalgıç, Aydın Gazi Üniversitesi - Transplantation Unit, Turkey
Abstract :
A 45-year-old woman from another country was suffering from dyspepsia, weight loss and early satiety. Her GGT and ALP levels were 1172 U/L and 369 U/L, respectively. Computed tomography (CT) of the abdomen revealed a 12x18 cm solid lesion in the right lobe and a 6x8 cm lesion in the left lobe of the liver (Figure 1a). The intrahepatic bile ducts were dilated. The biopsy results were consistent with a neuroendocrine tumor type I; the Ki67 proliferation index was 1%. Histology revealed a trabecular pattern coexisting with PGP 9.5, cytokeratin-19, chromogranin and CD56 positivity. CEA, HCC, insulin, gastrin, TTF-1 and CDX-2 staining was negative. It was suspected to be a primary liver neuroendocrine tumor. Positron emission tomography revealed pathological activity only in the liver. The tumor was subsequently deemed to be unresectable because of the inadequate remnant liver volume and liver transplantation (LT) was planned. Until the LT, long-acting somatostatin analogues were given to the patient.
