Altınova, Alev Eroğlu Gazi Üniversitesi - Endokrinoloji ve Metabolizma Bilim Dalı, Turkey , Aktürk, Müjde Gazi Üniversitesi - Endokrinoloji ve Metabolizma Bilim Dalı, Turkey , Törüner, Füsun Gazi Üniversitesi - Endokrinoloji ve Metabolizma Bilim Dalı, Turkey , Çakır, Nuri Gazi Üniversitesi - Endokrinoloji ve Metabolizma Bilim Dalı, Turkey , Arslan, Metin Gazi Üniversitesi - Endokrinoloji ve Metabolizma Bilim Dalı, Turkey

Evaluation of Apo B, Non-HDL Cholesterol Levels and Apo B/Apo A-1 Ratio in Patients with Type 2 Diabetes

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Objective: Apo B, non-HDL cholesterol (non-HDL-C) levels and ApoB/Apo A-1 ratio have been suggested to be as important as LDL cholesterol (LDL-C) in terms of increased risk of cardiovascular disease (CVD). We examined these parameters in patients with type 2 diabetes (T2DM). Methods: Forty patients with T2DM (21 females, 19 males) attending Diabetes Clinic of Gazi Medical Faculty were enrolled. Patients were not using statin and their serum LDL-C level were below 100 mg/dl. Results: The mean LDL-C was 85.6 }15.5 mg/dl, HDL-C,46.7 } 8.9 mg/dl, triglycerides,150.1 }71.8 mg/dl, non-HDL-C, 118.5 }22.4 mg/dl, Apo B-100, 81.5 }16.5 mg/dl, ApoA-1, 138.6 }22.4 mg/dl and ApoB/Apo A-1 ratio, 0.6 } 0,1. The percentages of the patients with high Apo B and high non-HDL-C were 29.7% and 21.6%. High Apo B/Apo A-1 ratio was found as 8.1%. In addition, serum Apo B levels showed a significant positive relationship with postprandial blood glucose (PBG)(r=0.36, p=0.02). Conclusion: In our study, we observed that approximately one third of thepatients with T2DM had high Apo B and one fifth had high non-HDL-C levels even if the LDL-C is on target values. For this reason, it is important that Apo B and non-HDL-C should be taken into consideration for the assessment of CVD risk in patients with T2DM. In addition, our finding that the relationship between PBG and Apo B suggests that postprandial glycemic control may have an impact on Apo B levels.

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Apolipoprotein B , Apolipoprotein A , 1 , Apolipoprotein B , Apolipoprotein A , 1 ratio , cardiovascular disease , non , HDL cholesterol , Type 2 Diabetes Mellitus

Gazi Medical Journal

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