Author/Authors :
İyidir, Özlem Turhan Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Özkan, Çiğdem Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Altınova, Alev Eroğlu Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Cerit, Ethem Turgay Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Çimen, Ali Rıza Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Değertekin, Ceyla Konca Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Altay, Mustafa Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Çölbay, Mehmet Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Göçün, Pınar Uyar Gazi Universitesi - Tip Fakultesi - Patoloji Anabilim Dali, Turkey , Taneri, Ferit Gazi Universitesi - Tip Fakultesi - Genel Cerrahi Anabilim Dali, Turkey , Aktürk, Müjde Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Törüner, Fusun Baloş Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Karakoç, Ayhan Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Yetkin, İlhan Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Ayvaz, Göksun Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Çakır, Nuri Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey , Arslan, Metin Gazi Universitesi - Tip Fakultesi - Iç Hastaliklari Anabilim Dali, Endokrinoloji ve Metabolizma Hastaliklari Bilim Dali, Turkey
Abstract :
Objective: Fine needle aspiration (FNA) biopsy and ultrasonography are the methods used to evaluate thyroid nodules and to predict malignancy together with the clinical characteristics of nodules. It is important to know false positive and false negative incidences of FNA especially in the case of follicular neoplasia or indeterminate lesions such as atypia of undetermined significance (AUS) to decide whether surgery is necessary or not. The aim of this retrospective study was to evaluate ultrasonographic characteristics of histopathologically verified malignant thyroid nodules and histopathologic correlation of cytologically indeterminate lesions with histopathologic diagnosis.Methods: One hundred and fifty-four patients who underwent thyroidectomy between January 2010 and January 2012 are included in this study. Demographic characteristics, cytological and histopathological results, preoperative TSH levels of all patients and ultrasonographic characteristics of the nodules were evaluated retrospectively. Results: Histopathology of 104 patients (67.5%) was benign and 50 patients (32.5%) was malignant. TSH levels in the group of benign pathology are significantly lower than the group of malignant ones. Sensitivity, specifity, positive predictive value and negative predictive value of FNA were calculated as 90.7%, 72.2%, 62.7%, 93.8%, respectively. Diagnostic accuracy of FNA was 78.5%. Incidence AUS was calculated as 7% and 25% of these lesions were histopathologically malignant. Hypoechogenicity (OR=2.3, p 0.05), microcalcifications (OR=2.5 p 0.05) and increased peripheral and central perfusion (OR=11 p 0.05) were the independent risk factors for malignancy. Conclusion: Cytological and hispathological findings of thyroid nodules in our study correlate with other studies. Hypoechoic nodules that have microcalsifications and increased peripheral and central perfusion are more likely to be malignant.
