Author/Authors :
Kaymak, Ayşegül Öztürk Ministry of Health - Dr A Y Demetevler Oncology Education and Research Hospital, Turkey , Sönmez, Çiğdem Ministry of Health - Dr A Y Demetevler Oncology Education and Research Hospital, Turkey , Çavdarlı, Büşranur Ministry of Health - Numune Education and Research Hospital, Turkey , Öztomurcuk, Senem Ministry of Health - Dr A Y Demetevler Oncology Education and Research Hospital, Turkey , Talayhan, Nurefsan Ministry of Health - Dr A Y Demetevler Oncology Education and Research Hospital, Turkey , Guntaş, Gülcan Ministry of Health - Dr A Y Demetevler Oncology Education and Research Hospital, Turkey
Abstract :
Acute myeloid leukemia (AML), phenotypically and genotypically is a quite heterogeneous disease. More than 100 cytogenetic aberrations and gene mutations that are specific to this disease are defined (1). A patient who applied to hematology polyclinic of our hospital with various complaints was diagnosed with AML. In genetic analyses, t(8;21) and FLT3-ITD were found to be positive. Additionally, in chromosome analysis trisomy 8 was observed. After remission was ensured in the patient, allogenic stem cell transplantation was carried out. By conducting t(8;21), FLT3 mutation and trisomy 8 analyses on the patient at regular intervals, prior information was gathered about the relapse and minimal residual disease.
NaturalLanguageKeyword :
Minimal Residuel Disease, acute myeloid leukemia, chimerism, trisomy 8, FLT3 mutation, t(8 , 21)
