Arpacı, Fikret Gülhane Askeri Tıp Fakültesi (GATF) - Tıbbi Onkoloji Bilim Dalı, Turkey

CD34 (+) cell selection and purging in hematopoietic cell transplantation

19919

Peripheral blood stem cells have replaced bone marrow as the primary source for autologous stem cell transplantation. Although tumor burden appears to be lower in peripheral blood stem cell fractions than in the bone marrow, modern detection methods can detect the tumor cell present in peripheral blood stem cell fractions. Tumor cells in the graft may contribute to relapses in posttransplant period. Purging of peripheral blood stem cell fractions can be done either by negative or positive selection. CD34 positive selection has been successfully used to deplete tumor cells from grafts for autologous transplantation, to deplete T cells for allogeneic transplantation, to enrich progenitor cells for gene therapy and ex-vivo expansion strategies of progenitor cells for 15 years.

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Purging , CD34 (+) cell , cell selection , positive and negative selection

Gulhane Medical Journal

231