Author/Authors :
Özan, Fatih Abant Izzet Baysal Üniversitesi - Dis Hekimligi Fakültesi, Turkey , Özdem, Muhsin Abant Izzet Baysal Üniversitesi - Dis Hekimligi Fakültesi, Turkey , Özan, Ülkü Abant Izzet Baysal Üniversitesi - Dis Hekimligi Fakültesi, Turkey , Sençimen, Metin GATA(Gülhane Askeri Tıp Akademisi) - Dis Hekimligi Bilimleri, Turkey , Polat, Zübeyde Akın Cumhuriyet Üniversitesi - Tıp Fakültesi, Turkey
Title Of Article :
Evaluation of Cytotoxic effect of Garlic on human gingival fibroblasts: A Preliminary Study
Abstract :
In this study we aimed to evaluate the cytotoxic effect of garlic extract on human gingival fibroblasts. Garlic extracts were prepared at 5 different concentrations as 12.5%, 6.25%, 3.12%, 1.5%, and 0.6%. Cytotoxic effects of garlic and clorhexidine gluconat (CH) on human gingival fibroblasts were evaluated by agar diffusion method at 24 h. Garlic extracts concentrations at 6.25, 3.12, and 1.5% were not found cytotoxic on human gingival fibroblasts, whereas concentration at 12.5% was found cytotoxic, this effect was found less cytotoxic than CH. According to results of this study we could suggest that Garlic would have a promising role in the future for oral health, if appropriate solutions can be prepared.
NaturalLanguageKeyword :
Garlic , chlorhexidin gluconat , human gingival fibroblast , cytotoxicity
JournalTitle :
Gulhane Medical Journal
