Author/Authors :
Lyonga, EE University of Yaoundé 1 - Faculty of Medicine and Biomedical Sciences - Department of Microbiology, Haematology, Parasitology and Infectious Diseases, Cameroon , Toukam, M University of Yaounde I - Faculty of Medicine and Biomedical Sciences - Department of Microbiology, Hematology, Parasitology, Immunology and infectious diseases, Cameroon , Atashili, J University Of Buea - Faculty of Health Sciences, Cameroon , Gonsu, HK University of Yaoundé 1 - Faculty of Medicine and Biomedical Sciences - Department of Microbiology, Haematology, Parasitology and Infectious Diseases, Cameroon , Adiogo, D University of Yaoundé 1 - Faculty of Medicine and Biomedical Sciences - Department of Microbiology, Haematology, Parasitology and Infectious Diseases, Cameroon , Mesembe, M University of Yaounde 1 - Faculty of Medicine and Biomedical Sciences, Centre for the Study and Control of Communicable Diseases, Cameroon , Nguefack-Tsague, G University of Yaounde 1 - Faculty of Medicine and Biomedical Sciences - Department of Public Health, Cameroon , Eyoh, A University of Yaounde I - Faculty of Medicine and Biomedical Sciences - Department of Microbiology, Hematology, Parasitology, Immunology and infectious diseases, Cameroon , Ikomey, G University of Yaounde I - Faculty of Medicine and Biomedical Sciences - Department of Microbiology, Hematology, Parasitology, Immunology and infectious diseases, Cameroon , Mukwele, B University of Yaounde 1 - Faculty of Medicine and Biomedical Sciences - Centre for the Study and Control of Communicable Diseases, Cameroun , Meli Tiabou, JM University of Yaoundé 1 - Faculty of Medicine and Biomedical Sciences - Department of Microbiology, Haematology, Parasitology and Infectious Diseases, Cameroon , Okomo Assoumou, MC University of Yaoundé 1 - Faculty of Medicine and Biomedical Sciences - Department of Microbiology, Haematology, Parasitology and Infectious Diseases, Cameroon
Abstract :
INTRODUCTION. Enterobactericeae are associated with many types of infections including abscesses, pneumonia, meningitis, septicaemia, and intestinal, urinary and wound infections. Fluoroquinolones (FQs) represent the drug of choice for the treatment of a wide range of human infectious diseases caused by enterobacteriaceae. This study aimed at comparing the susceptibility of six quinolones (Qs) of different generations that are often used in the empirical treatment of cases of suspected enterobacterial infections where susceptibility testing is not always systematic. METHODOLOGY. Three hundred enterobacteriaceae species were isolated from 13 different clinical specimens. Identification was done using Api 20E. Susceptibility testing was performed using the Kirby Bauer Disc Diffusion method using two Qs of first generation; nalidixic acid and pipemidic acid, and four FQs; two second generation; norfloxacin and ciprofloxacin, one third generation; sparmofloxacin and one fourth generation;moxifloxacin. RESULTS. The resistance of the different species to the first generation Qs was: Klepsiella 38/99(38.4%); Escherichia 38/108(35.2%); Enterobacter 7/24(29.8%); Proteus 5/24(20.8%); Serratia 6/21(28.6%); Salmonella 1/9(11.1%); Citrobacter 1/8(12.5%). The resistance to the FQs was: Klepsiella 31/99(31.3%); Escherichia 30/108(27.8%); Enterobacter 4/24(16.7%); Proteus 2/24(8.3%); Serratia 6/21(28.6%); Salmonella 0% and Citrobacter 1/24(12.5%); Overall, 99/300(33.0%) of isolates were resistant to the Qs and 77/300(25.7) to the FQs (P-value 0.05). CONCLUSION. This study has shown that overall there is no significant difference in the susceptibility between the Qs of the first generation and the FQs in the treatment of enterobacterial infections. The high of percentage quinolone resistance makes it necessary for us to use a rational in prescribing these drugs.
