Author/Authors :
Kouam Foubi, Brice Bertrand University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Chuisseu, Djamen Dieudonné University des Montagnes Bangangté - Faculty of Health Sciences, Cameroon , Dzeufiet Djomeni, Paul University of Yaoundé I - Faculty of Sciences, Cameroon , Samba Nganou, Odette University of Dschang - Faculty of Sciences, Cameroon , Tiedeu, Alain Bertin University of Yaoundé I - National Advanced School of Engineering, Cameroon , Monabang, Zoe Cathy University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Mbede, Maggy University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Moifo, Boniface University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Zeh, Odile Fernande University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Guegang Goujou, Emilienne University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Ongolo Zogo, Pierre University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Dong à Zok, Faustin University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Yomi, Jean University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Juimo, Alain Georges University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Mouelle, Sone University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Nko’o Amvene, Samuel University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon , Gonsu Fotsin, Joseph University of Yaoundé I - Faculty of Medicine and Biomedical Sciences, Cameroon
Abstract :
Introduction. Whole body irradiation results in blood glucose disturbances from the first hours post irradiation up to several days later. Aged garlic extract (AGE) has been demonstrated to possess several physiological activities in experimental animals thus; the present study was aimed at evaluating the possible protective effect of AGE on evolution of Glycaemia in Albino Wistar male rat’s post-acute whole body irradiation. Materials and Methods: Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. A slight bite to the distal tip (lateral vein) of rat tail enables to get a slight bleeding which was deposited on a reactive dipstick and the blood sugar reading was done using a glucometer. Results. Exposure of rats to gamma irradiation caused a significant elevation of blood glucose at 4:00, 24:00, a non-significant elevation at 48:00, then a non-significant increase at 72:00 and 96:00. In rats receiving AGE orally via gavage for 5 consecutive days prior to acute irradiation and one hour after irradiation on day 6 and for 7 consecutive days, the results showed an improvement in blood glucose evolution. Conclusion. AGE seems to have protective effects against radiation-induced changes in evolution of glycaemia.
