Author/Authors :
Doh, Gilbert University of Yaoundé 1 - Faculty of Medicine and Biomedical Sciences,Center for the Study and Control of Communicable Diseases(CSCCD), Cameroon , Ikomey, George Mondinde University of Yaoundé 1 - Faculty of Medicine and Biomedical Sciences, Center for the Study and Control of Communicable Diseases(CSCCD), Cameroon , Njenda, Duncan Stellenbosch University - Faculty of Medicine and Health Sciences - Division of Medical Virology, South Africa , Gichana, Josiah Stellenbosch University - Faculty of Medicine and Health Sciences - Division of Medical Virology, South Africa , Katusiime, Mary Grace Stellenbosch University - Faculty of Medicine and Health Sciences - Division of Medical Virology, South Africa , Ndze, Valantine Ngum Stellenbosch University - Faculty of Medicine and Health Sciences, Centre for Evidence-Based Health Care, South Africa , Zeier, Michelle AcademicTeaching Hospital Feldkirch - Department of Internal Medicine and Cardiology, Austria , Mesembe, Martha University of Yaoundé 1 - Faculty of Medicine and Biomedical Sciences, Center for the Study and Control of Communicable Diseases(CSCCD), Cameroon , Fokunang, Charles University of Yaoundé 1 - Faculty of Medicine and Biomedical Sciences, Cameroon , Okomo Assoumou, Marie Claire University of Yaoundé 1 - Faculty of Medicine and Biomedical Sciences, Cameroon , Tebeu, Pierre-Marie University of Yaoundé 1 - Faculty of Medicine and Biomedical Sciences, Cameroon , Atangana, Paul Adrien Centre Pasteur de Yaoundé, Cameroun , Jacobs, Graeme Brendon Stellenbosch University - Faculty of Medicine and Health Sciences - Division of Medical Virology, South Africa
Abstract :
Introduction – Aim. Cervical cancer, although largely preventable, remains the most common cause of cancer mortality amongst women in low-resource countries. Epidemiological and clinical studies have clearly established human papillomavirus (HPV) types 16 and 18 as the main cause of invasive cervical cancer (ICC). Despite the high burden of HPV (39.0%), high mortality due to cervical cancer in Cameroon, and availability of vaccines, quality reviews on HPV to inform effective public health control strategies are lacking. Methods. We carried out systematically search of 12 major electronic databases for published articles and grey literature up to May 2016 as per PRISMA guidelines. We included studies without language restriction that reported the prevalence of HPV genotypes 16 and 18 among Cameroonian women. Data was extracted and study quality appraised from 5 articles. Results. Our search strategy resulted in five eligible articles, including a total of 1856 women, age ≥18 years tested for HPV. The overall HPV prevalence in Cameroon observed in our systematic review was 36.3% (673/1856). The prevalence of HPV 16 and 18 were 13.0% and 6.5% in women with normal cytology, 18.2% and 4.6% in ASCUS, 29.7% and 27.0% in HSIL, 22.2% and 5.3% in women with ICC respectively. Conclusion. Our study shows that HPV16 and 18 account for 27.5% of ICC cases among Cameroonian women with a high HPV prevalence in women 25 years of age. These findings greatly support increased efforts in screening for high risk HPV genotypes and the introduction and roll out of HPV prophylactic vaccines in Cameroon.
