مرکز منطقه ای اطلاع رساني علوم و فناوري - Hypothermia and Hodgkin lymphoma in children

Abstract :

Hypothermia associated with Hodgkin lymphoma is defined rarely. This may be caused by a dysfunction that shall occur in hypothalamus, central and peripheral vascular system, skin and muscles. In this study, two Hodgkin lymphoma cases with developed hypothermia are presented.Case 1: A 7-year-old girl who applied to the hospital with complaints such as fever, weight loss and night sweating was diagnosed with “Hodgkin lymphoma, mixed cellular type” by a biopsy conducted due to lesions found in her spleen. While diagnostic works continued, the patient was administered paracetamol regularly for fever. The ABVD (adriamycin, bleomycin, vincristine, dacarbazine) therapy protocol was started to be applied on the patient. After chemotherapy was applied in the first day, hypothermia developed on the patient, but this healed spontaneously approximately 5 days later without requiring a further therapy.Case 2: A 9-year-old girl who applied to the hospital with complaints such as fever, itching and swelling on neck was diagnosed with “Hodgkin lymphoma, nodular sclerosing type” by a biopsy conducted by cervical lymph node.While diagnostic works continued, the patient was administered paracetamol regularly for fever. At this stage, hypothermia developed on the patient before the chemotherapy was applied. The ABVD therapy protocol was started to be applied on the patient. Hypothermia healed spontaneously approximately 3 days later without requiring a further therapy.Hypothermia in Hodgkin lymphoma depends probably on the amount of generated endogen pyrogens and accordingly on personally changeable negative feedback threshold of the sensitized hypothalamus.