Author/Authors :
Müslümanoğlu, Muhammed Hamza Yildiz Technical University - Faculty of Science and Arts - Department of Molecular Biology, Turkey , Basmacı, Tanju Eskisehir Osmangazi University - Faculty of Medicine - Department of Medical Genetics and Urology, Turkey , Ulusal, Selma Demir Eskisehir Osmangazi University - Faculty of Medicine - Department of Medical Genetics and Urology, Turkey , Aslan, Hüseyin Adana Numune Research and Education Hospital - Department of Medical Genetics, Turkey , Tepeli, Emre Denizli Pamukkale University - Medical Faculty - Department of Medical Genetics, Turkey , Özdemir, Muhsin Eskisehir Osmangazi University - Faculty of Medicine - Department of Medical Genetics and Urology, Turkey , Turgut, Mehmet Eskisehir Osmangazi University - Faculty of Medicine - Department of Medical Genetics and Urology, Turkey
Abstract :
Purpose: There is positive correlation between insulin and various cancers such as colon, lung and endometrium. Protate cancer is the one of them. The aim of this study, to determine the incidance of INS+1127 PstI polymorphism, located in the 3’ UTR of insulin gene, between prostate cancer cases and controls and to clarify if this polymorphism have any role in the etiology of prostate cancer. Methods: We investigated 71 prostate cancer cases and 119 normal controls unrelated to patients. INS+1127 PstI polymorphism was investigated with PCR and RFLP method.Results: At the end of study; INS+1127 PstI polymorphism genotypes out to be 67.6 % CC, 28.2 % CT, 4.2 % TT among prostatic cancer individuals and 78.2% CC, 21% CT, 0.8% TT among control group individuals. Conclusion: As a result, there was no significant difference between patients and control group, in the genotype distribution.
NaturalLanguageKeyword :
INS , polymorphism , prostate cancer , PSTI
