Soebagjo, Hendrian D. Brawijaya University - Medical Faculty - Department of Ophthalmology, Indonesia , Sujuti, Hidayat Dr. Saiful Anwar Hospital - Department of Biochemistry-Molecular Biology – Department of Ophthalmology, Indonesia , Machfoed, Hasan Airlangga University - Faculty of Medical, Dr Soetomo Hospital - Department of Neurology, Indonesia , Soemitro, Sutiman Bambang Brawijaya University - Faculty of Mathematic and Natural Sciences - Department of Biology, Indonesia

Expression of FasL in Proliferation of Retinoblastoma Cells: A Mechanism Fas Counterattack

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Purpose: The aim of this study were to determine the association of increasing of FasL with increasing proliferation of retinoblastoma cells.Materials and Methods: The protein expression was analyzed in 30 retinoblastoma samples from paraffin block using immunohistochemical method for evaluation of FasL, CDK4, and Ki-67 expression.Results: Among 30 retinoblastoma samples, FasL expression majority was negative in 33.3 % (10 samples) and strong in 36,8 % (11 samples). CDK4 majority 53,3% was weak expression and Ki-67 was high expression also in 53,3% (16 samples). The expression of FasL was significantly related to CDK4 (r: 0.363; p: 0.048). The CDK4 was also significantly related to Ki-67 expression (r: 0.601; p: 0.000).Conclusion: The increasing of FasL on the mechanism Fas counterattack induces proliferation of retinoblastoma cells.

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FasL , proliferation , counterattack , retinoblastoma

Cukurova Medical Journal

794