Author/Authors :
Yıldızdaş, Hacer Yapıcıoğlu Çukurova University - Faculty of Medicine - Department of Pediatrics, Division of Neonatology, Turkey , Yıldızdaş, Dinçer Çukurova University - Faculty of Medicine - Division of Pediatric Intensive Care, Turkey , Özlü, Ferda Çukurova University - Faculty of Medicine - Department of Pediatrics, Division of Neonatology, Turkey , Mert, Kurthan Adana Numune Training and Research Hospital - Neonatal Intensive Care Unit, Turkey , Mungan, Neslihan Önenli Çukurova University - Faculty of Medicine - Department of Pediatrics, Division of Metabolism, Turkey
Abstract :
In newborns, hyperammonemia leads to encephalopathy which is usually characterized by vomiting, hypotonia, lethargy, seizures and coma. Continuous venovenous hemodiafiltration (CVVHDF) is a modality choice to treat acute decompensation in hyperammonemia. Here we report three newborn patients with hypotonia, convulsion and hyperammonaemia. In the first three days of life, their serum ammonia levels were 4609, 1023 and 1949 μg/ml. They were successfully treated with CVVHDF and serum ammonia levels subsequently decreased to 268, 164 and 65 μg/ml in the first 24 hours of treatment. The complications were mild hypothermia and anemia.
