Author/Authors :
Kazgan, Tuğçe Adana Numune Eğitim ve Araştırma Hastanesi - Çocuk Sağlığı ve Hastalıkları Kliniği, Turkey , İlhan, Aysu Adana Numune Eğitim ve Araştırma Hastanesi - Çocuk Sağlığı ve Hastalıkları Kliniği, Turkey , Durmaz, Cemile Adana Numune Eğitim ve Araştırma Hastanesi - Çocuk Sağlığı ve Hastalıkları Kliniği, Turkey , Yağcı-Küpeli, Begül Adana Numune Eğitim ve Araştırma Hastanesi - Çocuk Sağlığı ve Hastalıkları Kliniği, Turkey
Abstract :
Carboplatin, commonly used chemotherapeutic agent in treatment of pediatric cancers, can cause life-threatening hypersensitivty reactions. Carboplatin hypersensitivity is protocol-specific and associated with repeated doses and prolonged use of the drug. Vincristin and carboplatin combination is used efficiently in treatment of pediatric low-grade gliomas. However, hypersensitivity reactions are frequently observed during usage of this protocol. Desensitization strategies with variable success rates were reported. Failure of these strategies may lead to cessation of carboplatin Here, we report two cases with carboplatin hypersensitivity treated with epinephrine administration, in whom carboplatin was discontinued after hypersensitivity reaction.
