Gelincik, Hakan Çukurova University - Faculty of Medicine - Department of Pediatric Oncology, Pediatric Bone Marrow Transplantation Unit, Turkey , Küpeli, Serhan Çukurova University - Faculty of Medicine - Department of Pediatric Oncology, Pediatric Bone Marrow Transplantation Unit, Turkey

Long term survival in a patient with recurrent metastatic Ewing sarcoma treated with irinotecan and temozolomide

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Ewing sarcoma family of tumor is the second most common bone tumor in children and young adults, after osteosarcoma. Different chemotherapeutic regimens are used in treatment of relapsed/recurrent Ewing sarcoma. Promising results were achieved with combination of irinotecan and temozolomide. Our case was a 13-year-old female with relapsed Ewing sarcoma and after 12 cycles of irinotecan (20 mg/m2/10 days) and temozolomide (100mg/m2/5 days) treatment she had not any complaints, and her radiological lesions remained stable for 66 months. Irinotecan and temozolomide have been used successfully in treatment of relapsed/recurrent Ewing sarcoma, but there is a need for randomized prospective studies with larger patient groups for establishing the efficacy of this treatment protocol.

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Ewing Sarcoma , irinotecan , temozolomide

Cukurova Medical Journal

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